Disease Associated Microglia Is Identified As A Major Contributor To Neuroinflammation Associated To Chronic Hypoxia Induced-Pulmonary Hypertension.

Aline C Oliveira, Mathew Alves,Ann Pham, Kelly Balman,Chunhua Fu,Laylo Mukhsinova,Elaine M Richards,Mohan K Raizada,Andrew J Bryant

FASEB journal : official publication of the Federation of American Societies for Experimental Biology（2022）

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摘要

While TREM2 contribution has been extensively studied in neurodegenerative diseases and cancer therapy, these experiments are the first to demonstrate the potential of Trem2 targeted therapy in context of PH. Moreover, we believe that data generated from these studies may lead to translational studies evaluating the potential of TREM2 as a therapeutic target for PH.

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