Role of GBP5 in NLRP3 inflammasome mediated intestinal inflammation in Crohn's disease.

GBP5 is required in the expression of many inflammatory cytokines and chemokines in intestinal immune cells. In addition, GBP5 may up-regulate inflammatory reactions through an inflammasome mediated mechanism. Highly elevated GBP5 expression at the inflamed colonic mucosa in two geographically and culturally distinct IBD cohorts indicates that GBP5 plays a common and important role in IBD pathogenesis, and therefore, is a potential therapeutic target for the management of IBD patients of various genetic and environmental backgrounds.