End-proximal tubule phosphate concentration increases as GFR falls in humans: measurement by means of a lithium clearance-based methodology.

Giacomo Colussi,Alberto Menegotto,Marialuisa Querques,Federica Ravera,Simona Verdesca,Valeriana Colombo,Enrico E Minetti

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association（2023）

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摘要

ePTpc progressively increases in humans as functional renal mass falls independently from plasma P levels. Main determinants of ePTpc rise are GFR fall, degree of phosphaturia per unit GFR and P intake corrected for GFR. It may become a novel, potentially useful, indicator to guide management of CKD patients.

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关键词

ESRD progression,intratubular phosphate concentration,microscopic nephrocalcinosis,phosphate excretion

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