IMMUNOlogical microenvironment in REctal Adenocarcinoma Treatment (IMMUNOREACT 2; NCT04917263): preliminary results on prediction of complete response to neoadjuvant therapy in rectal cancer

Gaya Spolverato,Melania Scarpa,Matteo Fassan,Valentina Chiminazzo,Imerio Angriman,Cesare Ruffolo, Luca Facci,Tommaso Stecca,Marco Massani,Ottavia De Simoni,Pierluigi Pilati,Giovanni Pirozzolo, Roberto Merenda, Bordignon Giovanni, Alice Bressan, Fabrizio Vittadello,Ignazio Castagliuolo,Andrea Porzionato,Salvatore Pucciarelli,Marco Scarpa

Ejso（2022）

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摘要

Background: After pathologic complete response (pCR) to neoadjuvant chemoradiotherapy (nCRT) for locally advanced rectal cancer (LARC) patients might be eligible for less radical surgery or non-operative management. A low stromal Treg density was observed more frequently in patients who had a pCR. Field cancerization concept means that some molecular events in carcinogenesis might occur even in normal tissues surrounding tumors. Our aim was to identify, among LARCs, those with complete response to nCRT analyzing the immune microenvironment in healthy mucosa.

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关键词

rectal adenocarcinoma treatment,neoadjuvant therapy,immunological microenvironment,immunoreact,cancer

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