Shape optimization of hotspot targeted micro pin fins for heterogeneous integration applications

•Demonstrated a novel energy-efficient design for hotspot mitigation employing 3D printed pin fins.•Studied the effect of fin geometry in background and hotspot region simultaneously.•Performed detailed parametric study to reduce the number of variables for optimization.•Demonstrated physics informed machine learning coupled with NSGA-II and determined the global optimal solution.•Determined the optimal (minimum) chip to coolant thermal resistance 0f 0.2 K-cm2/W under constrained pressure drop conditions.