A Practical and Scalable Preparation of Lusianthridin

The efficient preparation of the stilbenoid lusianthridin is described. This synthesis relies on the Suzuki‒Miyaura coupling and intramolecular nucleophilic substitution as key reactions to construct the 9,10-dihydrophenanthrene core. The synthesis is completed in 7 steps with a 13.2% overall yield, and each step can be conducted on > 20 grams scale. The route has provided 20 grams of lusianthridin for the further biological activity study.