The Damage to the Stem Cells by Diabetic and Dyslipidemic Milieu. Clinical Implications for Erectile Dysfunction and LUTS.

The obesity pandemic in the USA and worldwide has reached a previously unparalleled dimension, and not surprisingly, this has culminated into a significant increase in T2D incidence. 1 Aras M Tchang BG Pape J. Obesity and diabetes. Nurs Clin North Am. 2021; 56: 527-541 Abstract Full Text Full Text PDF PubMed Scopus (9) Google Scholar ,2 Tinajero MG Malik VS. An update on the epidemiology of type 2 diabetes: a global perspective. Endocrinol Metab Clin North Am. 2021; 50: 337-355 Abstract Full Text Full Text PDF PubMed Scopus (29) Google Scholar This very unhealthy association in T2D/O promotes and exacerbates multiple urological complications and interferes with their treatment, specifically ED, 3 Maiorino MI Bellastella G Giugliano D et al. From inflammation to sexual dysfunctions: a journey through diabetes, obesity, and metabolic syndrome. J Endocrinol Invest. 2018; 41: 1249-1258 Crossref PubMed Scopus (74) Google Scholar and also in some LUTS, such as, urinary incontinence (SUI) and benign prostatic hyperplasia (BPH) in men. 4 Calogero AE Burgio G Condorelli RA et al. Epidemiology and risk factors of lower urinary tract symptoms/benign prostatic hyperplasia and erectile dysfunction. Aging Male. 2019; 22: 12-19 Crossref PubMed Scopus (70) Google Scholar Female sexual dysfunction (FSD) and SUI (FSUI) are also highly prevalent in T2D/O women.