Epigenetic Dysfunction in T cells Impairs Airway Sensitization to Peanut and Reduces Anaphylaxis Severity

Camille Kapita,Robert Immormino,Johanna Smeekens,Kevin Thomas,Michael Kulis,Timothy Moran,Onyinye Iweala

The Journal of Allergy and Clinical Immunology（2022）

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摘要

Epigenetic histone modifications in T cells by UTX, a histone H3 lysine 27 (H3K27) demethylase, are critical for robust cellular and humoral immunity against chronic viral infections. Whether UTX-modulated epigenetic changes affect type 2 immunity, including allergic sensitization and antigen-driven anaphylaxis, is unclear.

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