How transmembrane helices of type 1 receptors transmit information: prediction of dimers with the Martini 3 coarse grained model
Biophysical Journal(2022)
摘要
Determination of the structure and dynamics of transmembrane (TM) domains of single-transmembrane receptors is key to understanding their mechanism of signal transduction across the plasma membrane. Although many studies have been performed on isolated soluble extra- and intracellular receptor domains in aqueous solutions, limited knowledge exists on the lipid embedded TM region. In this study, we predict the assembly of alternate configurations of receptor TM domain dimers using the Martini 3 force field for coarse-grain (CG) molecular dynamic simulations.
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关键词
Signal Transduction,Cell Membranes,Cell Signaling,Membrane Proteins
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