Hv1 channel is a key target in immunosuppression in myeloid-derived suppressor cells (MDSC)

Myeloid-derived suppressor cells (MDSCs) are a heterogeneous cell population that has a high immunosuppressive activity and proliferates in infections, inflammation and tumor microenvironments. In tumors, MDSCs exert immunosuppression mainly by producing reactive oxygen species (ROS), a process triggered by the NADPH oxidase 2 (NOX2) activity. In certain immune cells, NOX2 is functionally coupled with the Hv1 channel to support the sustained free-radical production. However, a functional expression of the Hv1 channel in MDSCs has not been reported yet.