Direct Oral Challenge is a Safe and Effective Strategy to Delabel Low-Risk Penicillin Allergy in Immunocompromised Patients Admitted to the ICU

Increasing evidence supports that adults with low-risk penicillin allergy labels (PALs) can be delabeled with direct oral amoxicillin challenge. Immunocompromised patients admitted acutely are at increased risk of infection and likely benefit disproportionately from delabeling. We investigated the efficacy, safety, effectiveness, and infection outcomes of immunodeficient patients with low-risk PALs delabeled in the intensive care setting.