P42.03 Predictive Factors of Response to PD-(L)1 Inhibitors in Patients With Advanced Non-Small Cell Lung and High PD-L1 Expression

Tumor PD-L1 expression is the only validated predictive biomarker in advanced NSCLC patients (pts) treated with PD-(L)1 inhibitors. Analysis of PD-L1 expression by immunohistochemistry has been validated in histological samples. Smoking and overweight have been described as predictive factors of better outcome, whereas bone metastases, antibiotics, corticosteroids and proton pump inhibitors as possible negative predictive factors. The aim of our study was to analyze different potential predictive factors to PD-(L)1 inhibitors in pts with advanced NSCLC and high PD-L1 expression.