Lck signaling inhibition causes improvement in clinical features of psoriatic inflammation through reduction in inflammatory cytokines in CD4+ T cells in imiquimod mouse model

•There is increased Lck expression in CD4+ T cells during psoriatic inflammation.•Lck is linked with increase in Th1/Th17 cells during psoriatic inflammation.•Blockade of Lck causes decrease in Th1/Th17 cells during psoriatic inflammation.•Blockade of Lck improves psoriasis-associated clinical/biochemical parameters.