Update on Exosomes in Aesthetics.

BACKGROUND:In dermatology, exosomes have been leveraged given their roles in wound healing, cell migration, extracellular matrix reconstruction, and angiogenesis. OBJECTIVE:The purpose of this article is to review the literature investigating the use of exosomes in skin rejuvenation and hair regeneration. MATERIALS AND METHODS:The PubMed database was searched for studies published through October 2021. RESULTS:Early preclinical studies in aesthetics have demonstrated promising effects of exosomes on skin rejuvenation and hair growth in in vitro and murine models. Despite this, only 1 clinical study has been published to date, and there are no FDA-approved products on the market. CONCLUSION:Variation in purification techniques and practical issues surrounding isolation, storage, scalability, and reproducibility of an exosome product represent ongoing hindrances to the movement of exosomes into the clinical sphere.