Maternal enzyme reprograms paternal DNA for healthy offspring

Yumiko K. Kawamura,Antoine H. F. M. Peters

Nature（2022）

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摘要

It emerges that high blood sugar deregulates the enzyme TET3 in the eggs of female mice, preventing it from properly modifying sperm-derived DNA when eggs are fertilized. This leads to metabolic defects in adult progeny.

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关键词

Diabetes,Epigenetics,Physiology

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