Specific amino acids regulate Sestrin2 mRNA and protein levels in an ATF4-dependent manner in C2C12 myocytes

Ran Sawa, Ayaka Ohnishi, Maya Ohno, Maika Nagata,Ikumi Wake,Yasuhiko Okimura

Biochimica et Biophysica Acta (BBA) - General Subjects（2022）

引用 4|浏览6

暂无评分

摘要

•Amino acids deprivation increased Sestrin2 mRNA and protein levels in C2C12 cells.•The addition of specific amino acids restored or further increased Sestrin2 levels.•Sestrin2 response to amino acids depended on ATF4.•Amino acids regulate ATF4 transcription and translation to modulate Sestrin2 levels.

查看译文

关键词

Sestrin2,Amino acid,ATF4,eIF2α,Nrf2,C2C12 cell

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要