A Biological Basis for Pharmacokinetics: The Remote Sensing and Signaling Theory

CLINICAL PHARMACOLOGY & THERAPEUTICS(2022)

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摘要
What do drug transporters and drug metabolizing enzymes (DMEs)-as well as the various regulatory proteins involved in the absorption, distribution, metabolism, and excretion (ADME) of drugs-really do?(1) To those coming from a non-pharmaceutical background, this seems a very reasonable, if not urgent, question. What do they really do? What is their true biological function?
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