Effects of Medical Face Masks on Physical Performance in Patients With Coronary Artery Disease or Hypertension

In this randomized, prospective monocentric study, 40 subjects with coronary artery disease or hypertension (cardiovascular disease [CVD] group) were assigned to either surgical mask (SM) or class 2 filtering facepiece mask (FFP2). They performed cycle ergometry exercise tests with progressive intensity until exhaustion with the assigned mask and another test with no mask (NM) in random order. A control group of 10 healthy subjects randomly performed 3 exercise tests with NM, SM, and FFP2, respectively. Blood pressure, heart rate, 12-lead electrocardiogram, exertion, shortness of breath, and capillary blood gases from the earlobe were documented. Across all groups, exercise testing with face masks resulted in a significantly reduced peak power output in watts compared with testing with NM (CVD group: SM vs NM: - 5.0 +/- 7.0%, p = 0.005; FFP2 vs NM: -4.7 +/- 14%, p = 0.03; control group: SM vs NM: -6.8 +/- 4.4%, p = 0.008; FFP2 vs NM: -8.9 +/- 6.3%; p = 0.01) without differences in hemodynamic parameters, such as maximum heart rate and systolic blood pressure. Wearing an FFP2 compared with NM resulted in significant higher carbon dioxide partial pressure (CVD group: FFP2: 36.0 +/- 3.2 mm Hg vs NM: 33.3 +/- 4.4 mm Hg, p = 0.019; control group: FFP2: 32.6 +/- 2.8 mm Hg vs NM: 28.1 +/- 1.7 mm Hg, p < 0.001) with corresponding differences in hydrogen carbonate and base excess, but not to a clinically critical extent. In conclusion, exercise testing with SM and FFP2 resulted in a significant reduction of peak power output without differences in hemodynamic parameters in subjects with preexisting CVD and in healthy subjects. (C) 2022 Elsevier Inc. All rights reserved.