A systematic review of blood eosinophils and continued treatment with inhaled corticosteroids in patients with COPD

Dagmar Abelone Dalin, Anders Løkke, Pernille Kristiansen, Charlotte Jensen,Kirsten Birkefoss, Hanne Rolighed Christensen, Nina Skavlan Godtfredsen,Ole Hilberg, Jeanett Friis Rohde,Anja Ussing, Charlotte Vermehren,Mina Nicole Händel

Respiratory Medicine（2022）

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摘要

Inhaled corticosteroid (ICS) in patients with chronic obstructive pulmonary disease (COPD) has been debated for 20 years. In our systematic literature review and meta-analysis, we addressed the following: Should patients with COPD and a blood eosinophil count (EOS) of, respectively, a) < 150 cells/μl, b) 150–300 cells/μl, and c) > 300 cells/μl continue treatment with ICS? Protocol registered in PROSPERO (CRD42020178110) and funded by the Danish Health Authority.

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关键词

Inhaled corticosteroid,Chronic obstructive pulmonary disease,Blood eosinophils,Eosinophil

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