A New Cu(II) Coordination Polymer: Crystal Structure and Treatment Activity on Non-Alcoholic Fatty Liver

In the current study, via using the mixed-ligand approach, a new Cu(II)-based coordination polymer (CP) with the chemical formula of [Cu(L)(CTP)](n) (1) has been successfully hydrothermally synthesized by employing the halogenated linear ligand 2-chloroterephthalic acid (H2CTP) and the flexible N-donor 1,2-bis(2-methylbenzimidazol-1-ylmethyl)benzene (L) as the co-ligands. Its treatment activity on the non-alcoholic fatty liver was determined and the related mechanism was explored at the same time. First of all, the western blotting assay was performed and the expression levels of the TAK1 in the liver cells was measured. Next, the relative expression levels of miRNA-191 were detected with real time RT-PCR. Analysis results that obtained from molecular docking simulation revealed that the detailed binding interactions between the Cu complex and the probe protein were mainly from the carboxyl groups.