Multicomponent Domino Reactions for the Synthesis of Variable Hydrogenated Imidazo[1,2‐a]pyridines
Asian Journal of Organic Chemistry(2022)
摘要
Autocatalyzed one‐pot multicomponent cyclization of polyfluoroalkyl‐3‐oxo ester and ethylenediamine with aldehyde is an effective approach to octa‐, hexa‐ and tetrahydroimidazo[1,2‐a]pyridines generated mainly due to the α,β‐unsaturated aldehyde addition, often formed in situ, to the 3‐oxo ester methylene fragment, followed by the pyridine backbone closure at one of the carbonyl groups.
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关键词
multicomponent cyclization,polyfluoroalkyl-3-oxo esters,aldehydes,ethylenediamine,imidazo[1,2-a]pyridines
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