Clinical perspectives for the use of total-body positron emission tomography (TB-PET)

In the last decade, PET scanners have benefited from new technologies such as TOF support, PSF correction and SiPM detectors. More recently, the increase of detector number allowed an axial FOV as large as a human body length in total-body PET (TB-PET) innovative systems. Two different scanners called Quadra(C) and uEXPLORER(C) have been respectively proposed by Siemens Healthineers and United Imaging Healthcare. These TB-PET have two major advantages over actual systems on the market: a gain in detection sensitivity and a possibility of whole-body dynamic multiple organs analysis [1,2]. More than reducing drastically the acquisition duration and/or injected activities, these systems open up very interesting clinical perspectives to address specific issues encountered in routine clinical practice and thus improve patient care. We aimed in this brief communication to highlight some situations for which a TB-PET might help to settle current clinical issues. (C) 2022 Elsevier Masson SAS. All rights reserved.