Development of a Continuous Photochemical Bromination/Alkylation Sequence En Route to AMG 423

The development of a photochemical bromination/alkylation sequence as part of a continuous process for the synthesis of an intermediate en route to AMG 423 is discussed. Highlights of this continuous process include a significant reduction in reaction time and the elimination of aqueous waste streams. Also discussed are mechanistic and kinetic studies offering insights into notable features of the photochemical bromination.