Controllable Synthesis of Silicon-Based Nanohybrids for Reliable Surface-Enhanced Raman Scattering Sensing

Comprehensive Summary Interface between metallic nanoparticles and dielectric silicon substrate can strongly confine electromagnetic field (EM-field) through its localized surface plasmons, together contributing great surface-enhanced Raman scattering (SERS) enhancement. Typically, silicon-based nanohybrids (metallic nanoparticles in situ grown on silicon substrate) have been widely employed as SERS-active substrates in sensing platforms for the detection of chemical and biological analytes. Silicon-based nanohybrids with surface plasmons allow amplifying Raman signals that associate molecular binding events by several orders of magnitude. Together with interfacial architectures for the specific binding of target analyte on the silicon-based nanohybrid surface, silicon-based nanohybrid-enhanced Raman scattering represents a promising method for increasing reliability and sensitivity. This review affords a presentation to the basics of SERS enhancement of silicon-based nanohybrid, illustrates current advances in controllable synthesis of silicon-based nanohybrid substrates, and outlines current implementations to sensors for reliable detection of ultralow amounts of analytes. What is the most favorite and original chemistry developed in your research group? The design and fabrication of silicon-based platform for long-term bioimaging and reliable biosensing analysis. What is the most important personality for scientific research? Cooperation and conscientiousness. What are your hobbies? What's your favorite book(s)? Music. History book. Who influences you mostly in your life? Family and supervisors. What is your favorite journal(s)? Nature serials, JACS, Angew. Chem., etc. Could you please give us some advices on improving Chinese Journal of Chemistry? Publishing original and significant discoveries.