P40.10 Brain Metastases in Patients with Non-Small Cell Lung Cancer Treated with Immunotherapy. Real World Data from a Tertiary Hospital in Spain

The metastatic involvement of the central nervous system (CNS) has been traditionally related with an ominous prognosis in non-small cell lung cancer (NSCLC). Immunotherapy (IO) has (dramatically changed) revolutionized the treatment of non-oncogene addicted NSCLC but its tumour effectivity in the CNS has not been well established. The aim of this study is to identify if CNS metastases in lung cancer patients continue to be a major problem and a major cause of mortality in patients treated with IO.