Development and validation of a novel quantitative BRCA1 promoter methylation assay in ovarian carcinoma

Isabel Rodriguez,Christina Smith,Christopher Pennil,Marc Radke,Sarah Bernards,Enna Manhardt,Alexander Dobrovic,Eric Konnick,Elizabeth Swisher

Gynecologic Oncology（2022）

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摘要

BRCA1 methylation may confer homologous recombination deficiency (HRD) in ovarian carcinomas and loss of methylation can be a mechanism of therapeutic resistance. We sought to develop and validate a clinical grade, quantitative assay for BRCA1 promoter methylation and characterize the impact of BRCA1 methylation in ovarian carcinoma.

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ovarian carcinoma

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