CRISPR-based in situ engineering tumor cells to reprogram macrophages for effective cancer immunotherapy
Nano Today(2022)
摘要
•A selective responsiveness accelerated gene delivery system was constructed.•The gene delivery system rendered tumor-specific CD47 knockout and engineered tumor cells into factories of IL-12.•Combination of CD47 blockade and IL-12 production synergistically promoted the macrophage-mediated immunotherapy.
更多查看译文
关键词
CD47 blockade,IL-12 production,Selective responsiveness accelerated gene delivery system,TAM polarization,CRISPR/Cas9
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要