Cyperensol A, a novel sesquiterpenoid with a unique 6/6/5 skeleton from Cyperus rotundus L.

Qiang Wang,Jia-hao Lou, Zi-yan Zhao,Wen-lan Duan, Ji-hong Wang,Guang-zhi Zeng,Jun-lin Yin

TETRAHEDRON LETTERS（2021）

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摘要

A novel sesquiterpenoid, named Cyperensol A (1), was isolated from the rhizomes of Cyperus rotundus L. Its structure was elucidated extensively by the spectroscopic analysis. Possible biosynthetic pathway of 1 was proposed. Compound 1 showed inhibitory activity on IL-6 induced activation of JAK/STAT3 signaling pathway with IC50 value of 189.37 +/- 7.20 mu M. (C) 2021 Elsevier Ltd. All rights reserved.

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关键词

Cyperensol A, Sesquiterpenoid, Cyperus rotundus L., Inhibitor, JAK/STAT3 signaling pathway

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