Antigen transfer from non-APCs to APCs impacts the efficacy and safety of protein- and mRNA- based vaccines

Yingying Shi,Yichao Lu,Bing Qin,Mengshi Jiang,Xuemeng Guo,Xiang Li,Yu Liu,Jiaxin Huang,Junlei Zhang,Zhenyu Luo,Hang Yin,Huihui Liu,Guannan Guan,Yongzhong Du,Ling Peng,Jian You

Nano Today（2021）

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摘要

•Compared with professional APCs, most non-APCs demonstrate higher competence in mRNA-transfection and protein-uptake;•Vaccinated non-APCs activate specific immunoresponse by communicating antigenic information with nearby APCs;•Such antigenic communication is influenced by different determinants for mRNA vaccine and protein-based vaccine;•Such “off-target” immunostimulation is closely related to the efficacy and safety of vaccines.

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关键词

MRNA- or protein- based vaccine,Delivery route,Non-APCs,Antigen transfer,Secretory trait

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