Microstructural damange of white matter in the frontal Aslant tract in amnestic mild cognitive impairment subtypes

Frontal Aslant Tract (FAT) is a bundle connecting Broca's area to Supplementay Motor Area (SMA) and pre-SMA in both hemispheres, which has been traditionally implicated in speech functions (Catani et al., 2013). A previous study (Serra et al., 2017) showed microstructural damage of FAT in patients with Alzheimer's disease (AD) at the stage of dementia. We assessed here microstructural integrity/damage of FAT in patients with amnestic Mild Cognitive Impairment (aMCI) and its potential role in cognitive dysfunctions.