Long noncoding RNA GK-IT1 promotes esophageal squamous cell carcinoma by regulating MAPK1 phosphorylation.

Xin Yang,Tianyang Zeng,Ziyang Liu, Wanlun He,Mengting Hu,Ti Tang,Li Chen,Lei Xing

Cancer medicine（2022）

引用 7|浏览5

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摘要

Our study revealed that GK-IT1 competed with DUSP6 to attenuate the interaction between DUSP6 and MAPK1, leading to activation of the ERK/MAPK pathway, thereby promoting progression of ESCC. Our research indicated that GK-IT1 served as a novel potential target for the diagnosis and treatment of ESCC.

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关键词

ERK/MAPK pathway,MAPK1,esophageal squamous cell carcinoma,long noncoding RNA GK-IT1,malignant progression

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