Adjuvant hypofractionated radiotherapy with simultaneous integrated boost after breast-conserving surgery: A systematic literature review

•Simultaneous integrated boost seems effective and safe when given hypofractionated whole-breast irradiation.•The prescribed dose to the whole breast varied from 40 to 46.8 Gy. The number of fractions varies from 15 to 20 fractions.•The prescribed dose per fraction to the boost varied from 2.4 Gy per fraction to 3.4 Gy per fraction for a total boost dose from 48 to 52.8 Gy.•Regarding local control, no study reported local recurrence in patients treated with simultaneous integrated boost.