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Transcribed Ultraconserved Regions in Cancer

Myron K. Gibert,Aditya Sarkar,Bilhan Chagari,Christian Roig-Laboy,Shekhar Saha,Sylwia Bednarek,Benjamin Kefas,Farina Hanif,Kadie Hudson,Collin Dube,Ying Zhang,Roger Abounader

CELLS（2022）

Cited 4|Views21
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Abstract
Transcribed ultraconserved regions are putative lncRNA molecules that are transcribed from DNA that is 100% conserved in human, mouse, and rat genomes. This is notable, as lncRNAs are typically poorly conserved. TUCRs remain very understudied in many diseases, including cancer. In this review, we summarize the current literature on TUCRs in cancer with respect to expression deregulation, functional roles, mechanisms of action, and clinical perspectives.
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Key words
TUCR,ultraconserved,cancer,long non-coding RNA
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