Orthodontic canine substitution vs. implant-supported prosthetic replacement for maxillary permanent lateral incisor agenesis: A systematic review.

The results of MLIA treatment with SC were more favorable esthetically, but the difference was not statistically significant. There is no statistically significant data related to periodontal health, and neither of the treatment methods caused TMJ or occlusion morphology disorders. If both methods are available, space closure is preferable, although high-quality clinical trials are needed to find more evidence.