TRPA1 promotes melanosome phagocytosis in keratinocytes via PAR-2/CYLD axis

Yupeng Wang,Zhou Li,Wei Wu,Ying Liu,Yu Xiao, Dongdong Qi,Guangming Zhao,Meijuan Zhou,Hua Wang,Jing Liu,Zhiqi Song

Journal of Dermatological Science（2022）

引用 5|浏览12

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摘要

•TRPA1 mediated the phagocytic activity of keratinocytes.•TRPA1 knockdown markedly suppressed melanosome transport to keratinocytes.•TRPA1 activation indirectly stabilized microtubules via competitive binding.•Topical application of PS-341 causes pigmentation effects in vivo.

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关键词

TRPA1,PAR-2,Acetylate α-tubulin,Phagocytosis,Melanosome,PS-341

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