Whip- and pinworm infections elicit contrasting effector and distinct regulatory responses in wild house mice

•Nematode-infected wild house mice reflect type-1 vs type-2 immune bias seen in experimental whip- and pinworm infections.•Th1 expansion is accompanied by a rise in IL-10+ Th1 cells irrespective of infection status.•Elevated type-2 activity in pinworm infection is paired with expanded regulatory T cells.