CSF circulation and dispersion yield rapid clearance from intracranial compartments
Frontiers in Bioengineering and Biotechnology(2022)
摘要
In this paper we used a computational model to estimate the clearance of tracer driven by circulation of cere-brospinal fluid (CSF) produced in the choroid plexus (CP) located within the lateral ventricles. CSF was assumed to exit the subarachnoid space (SAS) via different outflow routes such as the parasagittal dura, cribriform plate and/or meningeal lymphatics. We also modelled a reverse case where fluid was produced within the spinal canal and absorbed in the CP in line with observation on certain iNPH patients. No directional interstitial fluid flow was assumed within the brain parenchyma. Tracers were injected into the foramen magnum. The models demonstrate that convection in the SAS yield rapid clearance from both the SAS and the brain interstitial fluid (ISF) and can speed up intracranial clearance from years, as would be the case for purely diffusive flow, to days.
### Competing Interest Statement
The authors have declared no competing interest.
更多查看译文
AI 理解论文
溯源树
样例
![](https://originalfileserver.aminer.cn/sys/aminer/pubs/mrt_preview.jpeg)
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要