Functional connectivity dynamics reflect disability and multi-domain clinical impairment in patients with relapsing-remitting multiple sclerosis

Amy Romanello,Stephan Krohn,Nina von Schwanenflug,Claudia Chien,Judith Bellmann-Strobl,Klemens Ruprecht,Friedemann Paul,Carsten Finke

NeuroImage: Clinical（2022）

引用 3|浏览7

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摘要

•Patients with early-MS show distinct alterations in functional connectivity dynamics.•Multi-domain clinical outcome scores scale with disability status scores in patients.•Temporal network dynamics vary with disability status in early MS.•Frontoparietal–basal ganglia decoupling is a novel, clinically-relevant signature of MS.

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关键词

Multiple sclerosis,Functional connectivity,Resting state,Brain dynamics,Disability,Functional magnetic resonance imaging

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