A Route to Lipid ALC-0315: a Key Component of a COVID-19 mRNA Vaccine

Fariba Saadati,Silvia Cammarone,Marco A Ciufolini

CHEMISTRY-A EUROPEAN JOURNAL（2022）

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摘要

This paper describes a synthesis of ALC-0315 by a sequence that more than doubles the overall yield relative to the published one, and that employs much cleaner reactions, thereby facilitating purifications to a considerable extent

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关键词

lipids, reductive amination, RNA therapeutics, vaccines

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