Viral protein activates the NLRP1 inflammasome

Nature Immunology（2022）

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摘要

Inflammasomes function as immune-signaling platforms that assemble following pathogen detection. Direct binding of a viral protein to NLRP1 and the disruption of a previously unknown autoinhibitory NRLP1 complex drive the activation of the NLRP1 inflammasome independently of the proteasome.

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关键词

Antimicrobial responses,Inflammasome,NOD-like receptors,Viral infection,Biomedicine,general,Immunology,Infectious Diseases

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