Multifunction in One Nanoparticle for Anticancer Therapy: Bowl-Shaped Au@PDA Yolk-Shell NPs
ACS APPLIED MATERIALS & INTERFACES(2022)
摘要
Multifunctional nanoparticles (NPs) with simultaneous multimodal therapeutic and imaging capabilities are very necessary for biomedical applications. We successfully prepared bowl-shaped gold@ polydopamine yolk-shell NPs (bowl-shaped Au@PDA YNPs) by a novel and facile method. The unique bowl-like structure enables a drug loading rate of 92% (920 mu g mg(-1)). The bowl-shaped Au@PDA YNPs are biocompatible, have good photothermal conversion and strong nearinfrared (NIR) absorption, and can control drug release under pH/NIR dual response. Bowl-shaped Au@PDA YNPs can also be employed as contrast agents for computed tomography/photoacoustic imaging for dual-modal imaging-guided chemotherapy and photothermal therapy due to the presence of Au NPs.
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关键词
bowl-shaped nanoparticles, pH/NIR dual-responsive properties, photothermal therapy, chemotherapy, CT/PA imaging
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