COVID-19 rapidly increases MDSCs and prolongs innate immune dysfunctions
EUROPEAN JOURNAL OF IMMUNOLOGY(2022)
摘要
We used unsupervised immunophenotyping of blood leukocytes and measured cytokine production by innate immune cell exposed to LPS and R848. We show that COVID-19 induces a rapid, transient upregulation of myeloid-derived suppressor cells (MDSCs) accompanied by a rapid, sustained (up to 3 months) hyporesponsiveness of dendritic cells and monocytes. Blood MDSCs may represent biomarkers and targets for intervention strategies in COVID-19 patients.
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关键词
COVID-19,Cytokines,Dendritic cells,Monocytes,Myeloid-derived suppressor cells
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