p75NTR Ectodomain Ameliorates Cognitive Deficits and Pathologies in a Rapid Eye Movement Sleep Deprivation Mice Model

Yang Zhu, Min Gao,Hao Huang,Shi-Hao Gao,Ling-Yi Liao,Yong Tao,Huan Cheng,Chang-Yue Gao

Neuroscience（2022）

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摘要

•Shedding of soluble extracellular domain of p75NTR (p75ECD) is reduced in SD.•Intraperitoneal injection of p75ECD-Fc (10 mg/kg) rescues cognitive decline of SD mice.•p75ECD-Fc alleviates SD-induced hippocampal neuronal apoptosis, synaptic plasticity impairment, and neuroinflammation.

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关键词

Aβ,Bax,Bcl-2,CRD,CSF,CUMS,GFAP,Iba1,IFN-γ,IL-1β,IL-6,ISF,MMPM,OFT,p75ECD,p75NTR,PSD95,REM,SD,SNAP25,SYN1,TACE,TNF-α,TUNEL

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