Detecting ongoing disease activity in mildly affected multiple sclerosis patients under first-line therapies

M. Pawlitzki,L. Masanneck,L. Rolfes,L. Regner-Nelke,A. Willison, S. Raeuber,F. Steffen,S. Bittner,F. Zipp,P. Albrecht,T. Ruck,H. -P. Hartung,S. Meuth

Multiple Sclerosis and Related Disorders（2022）

引用 8|浏览16

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摘要

•Even among MS patients considered mildly affected, most showed disease activity•Driven by MRI activity, loss of NEDA-3 was the most frequent marker of disease activity•PIRA occurred in 50% of patients and was often not accompanied by loss of NEDA-3•MRI and clinical measurements often did not show disease activity simultaneously•Measuring different disease activity outcome measures could improve monitoring

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关键词

Relapsing-remitting multiple sclerosis,Neurofilament light chain,PIRA,NEDA,RAW,Early MS,Disease activity measurements,Biomarker

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