Physiologically based pharmacokinetic combined JAK2 occupancy modelling to simulate PK and PD of baricitinib with kidney transporter inhibitors and in patients with hepatic/renal impairment

Regulatory Toxicology and Pharmacology（2022）

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Baricitinib,DDI prediction,Hepatic/renal impairment prediction,JAK-2 occupancy,PBPK-JO model

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