Photophysical Characterization and Fluorescence Cell Imaging Applications of 4-N-substituted Benzothiadiazoles
RSC advances(2022)
摘要
In this work, a series of fluorescent 2,1,3-benzothiadiazole derivatives with various N-substituents in the 4-position was synthesized and photophysically characterized in various solvents. Three compounds emerged as excellent fluorescent probes for imaging lipid droplets in cancer cells. A correlation between their high lipophilicity and lipid droplet specificity could be found, with log P >= 4 being characteristic for lipid droplet accumulation.
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关键词
Photoactivatable Probes,Fluorescence Correlation Spectroscopy
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