P323. Blunted Amygdala Activity to Positive Memories in Young Adults With High Familial Risk for Depression

Depression is associated with a tendency to recall fewer specific and fewer positive autobiographical memories (AMs), and reduced amygdala hemodynamic activity when recalling positive AMs. This amygdala response may be a causal mechanism underlying depression, yet whether it is a precursor to disease onset is unclear. This study evaluates if blunted amygdala activity during positive AM recall is detectable in healthy individuals at risk for major depressive disorder (MDD), to inform its utility as an early therapeutic target aimed at disease prevention.