Sulfur-Containing Pyrazoles, Pyrazolines and Indazoles

The review summarizes the literature and our own results over the past ten years (2011–2021) on the synthesis of heterocyclic compounds having the pyrazole, pyrazoline, or indazole nucleus, which are the basic elements for the design of drug-like compounds with multiple biological activities. Over the years, there has been a clear upward trend in the publication activity of the scientific community, which is expressed in the development of new synthetic methodologies, catalysis, and structural diversity to expand application of this privileged class of compounds. This chapter presents our effort aimed at systematizing the latest advances in the directed synthesis and biological activity of sulfur-containing 1,2-azoles, in which the sulfur atom is bonded directly to the ring or through the spacers. The current trends in organic synthesis and medicinal chemistry are shown in convergence with the principles and metrics of green chemistry such as “metal-free” and “solvent-free” reactions, green solvent, homo- and heterogeneous catalyst, multicomponent reactions (MCR), one-pot process, atomic efficiency, molecular docking, primary screening.