Evaluation of Intensive Vs Standard Blood Pressure Reduction and Association with Cognitive Decline and Dementia

Key Points Question Is intensive blood pressure reduction associated with lower rates of cognitive decline and dementia? Findings In this systematic review and meta-analysis of 5 randomized clinical trials with 17 396 participants, there was no significant association of lower blood pressure targets vs standard blood pressure management with the incidence of cognitive decline, dementia, and mild cognitive impairment in middle-aged and older adults with hypertension. Meaning These findings suggest that current evidence does not support intensive blood pressure reduction as a preventive strategy for cognitive decline and dementia.