Ovarian hormones, site-specific nociception, and hypertension

Accurate diagnosis and treatment of pain is dependent on knowledge of the variables that might alter this response. There is no doubt that the neuronal pathway activated , the sex, the hormonal profile, and the presence of chronic diseases are interconnected and thus contributes to the difficult to analyze nociception . Among these chronic diseases, hypertension is considered a prevalent and silent disease that has been associated with hypoalgesia in some experimental settings. In summary, this chapter explores the relationship between hypertension and pain with the contribution of sexual and site-specific differences, which is of great physiopathological and clinical interest in the field of pain.